The syllabus below describes the course activities over the semester, as
well as ancillary materials that can be used for information.
Enrolled students can go to the Student Participant Page (password
protected) to get course materials as they are made available.
BIOMARKERS IN TOXICOLOGY
ENTX 6431
Spring 2000
Instructor: Mike Hooper / 885-0229
TA: Tony Huang
Lecture:
Monday 10:00 - 10:50 TIEHH Auditorium
Laboratory Discussion: Monday 11:00 - 12:00 TIEHH Auditorium
Laboratory:
Wednesday 1:00 - 7:00 TIEHH Auditorium and Labs
Note: Some labs may be held in other locations on campus
___________________________________________________________________________________________
Week of Lecture Topic
Lab Topic
Contributors
___________________________________________________________________________________________
January 17 Biomarkers and Their Application
GLP, Notebooks,
Report Format/Reqts. Hooper / Huang
January 24 Biomarker Characterization
Biomarker Characterization (R)
Hooper / Huang
January 31 Cholinesterases / Carboxylesterases
ChE Assay and Reactivation (R)
Hooper / Huang
February 7 Exam / Sedimentation/DNA techniques
Microsome/cytosol/DNA preparation
Dickerson
February 14 Mixed Function Oxygenases
EROD and PROD and Protein (R)
Dickerson
February 21 Conjugative Enzymes
Glutathione-S-Transferase (R)
Dickerson
February 28 Estrogenicity
Estrogenicity (R)
Dickerson
March 6 Exam / Porphyrin Profiles
Porphyrin profiles (R) Initiate Dosing
Study Hooper / McBride
March 13 SPRING BREAK
SPRING BREAK
SPRING BREAK
March 20 Histopathology
Histopathology
Tandler
March 27 Microbial/Fungal Community Function
Fungilog/Biolog Assays (R)
ZAK
April 3 Final Exam
Dosing Study Termination / Sample Preparation Huang
for Assays and Histopathology
April 10 Student Projects Student Projects
Huang
April 17 Student Projects Student Projects
(R
- Due April 21, Noon)
Huang
April 24 Dosing Study Compilation (no
class) (R
- Due April 28, 4PM)
Huang
May 1 Final Week: No Class
___________________________________________________________________________________________
(R) - Indicates lab report due at the beginning of the next week's lab
Grading: Laboratory Reports (8) - 50%, Exams (3) - 30%, Final Group Project Report -
20%. Laboratory Reports: Standard journal paper format. Due at beginning of subsequent
week's laboratory. 5% loss of score for each day late, starting at 1:00 PM on day of lab.
Laboratory Discussions: Review findings and interpretation of previous lab as needed.
Text: None required. All readings from reserve materials and handouts.
Supplemental Texts:
- Huggett, R.J., Kimerle, R.A., Mehrle, P.M.,Jr., Bergman, H.L., eds.: Biomarkers:
Biochemical, Physiological, and Histological Markers of Anthropogenic Stress. Lewis
Publishers, Boca Ratan, FL, 1992.
- McCarthy, J.F., Shugart, L.R., eds.: Biological Markers of Environmental Contaminants.
Lewis Publishers, Boca Ratan,1990.
- Peakall, D.B.: Animal Biomarkers as Pollution Indicators, Ecotoxicological Series 1.
Chapman and Hall, London, 1992.
- Fossi, M.C., Leonzio, C., eds.: Nondestructive Biomarkers in Vertebrates. Lewis
Publishers, Boca Ratan, FL, 1994.
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