Published Abstracts:

 

            Xu, L., Afriyie-Gyawu, E., Jiang, Y., Tang, L., Huebner, H. J., Ankrah, N.-A., Ofori-Adjei, D., Ellis, W. O., Jolly, P. E., Williams, J. H., Wang, J.-S., Phillips, T. D. (2008).  NovaSil clay intervention in Ghanaians at high risk for aflatoxicosis: Immune parameters as biomarker of effect.  Toxicologist, 102, 490

 

Kolli, V., Tang, L., Wang, J.-S. (2008). Comparative and combinative cytotoxic effects of aflatoxin B1 and fumonisin B1 on human esophageal cells. Toxicologist, 102, 485.

 

Wang, J.-S., Xu, L., Cai, Q., Tang, L., Sun, G., Hu, X., Su, J. (2008). Validation of urinary free fumonisin B1 as a biomarker of exposure. Toxicologist, 102, 701.

 

Chen, L., Shao, C., Tian, G., Tang, L., Wang, J.-S., Gao, W. (2008). Cytotoxicity and CRM1 down-regulation of 4-(methylnitro-samino)-1-(3-pyridyl)-1-butanone in human bronchial epithelial cell line. Toxicologist, 102, 865.

 

Johnson, N., Cardona, A., Robinson, A., Taylor, J., Afriyie-Gyawu, E., Xu, L., Tang, L., Ankrah, N-A., Ofori-Adjei, D., Williams, J. H., Wang, J.-S., Phillips, T. D. (2008) Urinary 1-hydroxypyrene: a biomarker for polycyclic aromatic hydrocarbon exposure in a Ghanaian population  Toxicologist, 102, 1478.

 

Tang, L., Xu, L., Afriyie-Gyawu, E., Wang, P., Tang, Y., Wang, Z., Huebner, H. J., Ankrah, N.-A., Ofori-Adjei, D., Ellis, W. O., Jolly, P. E., Williams, J. H., Wang, J.-S., Phillips, T. D. (2008).   Aflatoxin exposure decreases serum levels of vitamins A&E in Ghanaians at high risk for aflatoxicosis. Toxicologist, 102, 2238.

 

Tang, Y., Tang, L., Wang, Z., Shao, C., Yu, J., Huang, T., Gao, W., Wang, J.-S. (2008). Interaction between phenotypic oxidative DNA damage biomarker and polymorphic DNA repair genes in high-risk population for liver cancer, Proc. AACR, 49, 1893.

 

Wang, P., Tang, L., Yu, J., Huang, T., Wang, J.-S. (2008). Long-term green tea polyphenol intervention decreases urinary 8-hydroxydeoxyguanosine levels in a high-risk population for liver cancer, Proc AACR, 49, 2125.

 

Wang, Z., Tang, L., Sun, G., Hu, X., Gao, W., Wang, J.-S. (2008). Interactions between environmental carcinogen exposure and genetic polymorphisms in human esophageal carcinogenesis, Proc. AACR, 49, 3916.

 

Shao, C., Chen, S., Chen, L., Hu, X., Tang, L., Sun, G., Cobos, E., Wang, J.-S., Haab, B. B., Gao, W. (2008). Antibody Microarray Analysis of Serum Glycans in Esophageal Squamous Cell Carcinoma Cases and Controls, Proc. AACR, 49, 3963.

 

Xu, L., Tang, L., Yu, J., Huang, T., and Wang, J.-S. (2007) Hepatitis B virus genotypes and 1762T/1764A double mutations and risk of hepatocellular carcinoma in southern Guangxi, China. Proc AACR, 48:1736

 

Wang, Z., Tang, Y., Cai, Q., Xu, L., Sun, G., Hu, X., Tang, L., Gao, W., Cox, S. B. and Wang, J.-S. (2007) Antioidant vitamins and green tea polyphenols and risk of esophageal squamous cell carcinoma in Huaian, China. Proc. AACR. 48:862

 

Tang, L., Jin, T., Wang, J.-S (2007) The protective effects of lycopene on cadmium induced gene expression and lipid peroxidation in rats. Toxicologist, 96:1929.

 

Sun, G., Wang, S., Hu, X., Su, J., Cai, Q., Tang, L., Gao, W., and Wang, J.-S (2007) Food co-contamination and human dietary exposure of aflatoxin B1 and fumonisin B1 in China. Toxicologist, 96:1451

 

Wang, P., Tang, Y., Xu, L., Tang, L., Afriyie-Gyawu, E., Huebner, H. J., Ankrah, N.-A., Ofori-Adjei, D., Williams, J. H., Wang, J.-S. and Phillips, T. D. (2007) Three-month clinical intervention trial of NovaSil clay in Ghanaians: Reduced of serum aflatoxin-albumin adduct levels. Toxicologist, 96:1454

 

Wang, Z., Xu, L., Guan, H., He, X., Tang, L., Afriyie-Gyawu, E., Huebner, H. J., Ankrah, N.-A., Ofori-Adjei, D., Williams, J. H., Wang, J.-S., and Phillips, T. D. (2007) Three-month clinical intervention trial of NovaSil clay in Ghanaians: No influence on utilization of vitamins A and E. Toxicologist, 96:1455

 

Afriyie-Gyawu, E., Ankrah, N-A., Xu, L., Tang, L., Huebner, H., Ofori-Adjei, D., Johnson, N. M., Sarpong, N., Williams, J. H., Wang, J.-S., Phillips, T. D. (2007). Three-month intervention trial with NovaSil clay in Ghanaians: Study design and clinical outcomes. Toxicologists, 96:1452

 

Johnson, N. M., Robinon, A., Sarpong, N., Afriyie-Gyawu, E., Huebner, H., Xu, L., Tang, L., Ankrah, N-A., Ofori-Adjei, D., Williams, J. H., Wang, J.-S., Phillips, T. D. (2007). Three-month intervention trial with NovaSil clay in Ghanaians: Study design and clinical outcomes. Toxicologists, 96:1453

 

Wang, Z., Tang, Y., Sun, G., Xie, Y., Wang, S., Hu, X., Tang, L., Wang, J.-S. (2006). Genetic polymorphisms of DNA repair enzyme XRCC1 and alcohol metabolizing enzymes ALDH2, ADH2, and ADH3 on susceptibility to esophageal cancer in Huaian, China, Porc AACR 47:2053.

Yu, J., Huang, T., Zhang, L., Wei, Z., Liang, R., Li, Y., Wang, K., Shi, J.,  Luo, H., Tang, L., Tang, Y., Zhang, Z-Q., Wang, J.-S. (2006). Chemoprevention Trial of Green Tea Polyphenols in High-Risk Population of Liver Cancer in Southern Guangxi, China, Proc AACR 47: 4886.

Liu, F, Wang, J.-S., Hooper, M.J., and Theodorakis, CW. (2006) Evaluation on toxicity of sodium perchlorate and sodium arsenate using zebrafish Danio Rerio as a model: genotoxicity and oxidative stress perspective. Toxicologist 90:1191.

 

Wang, Z., Tang, Y., Luo, H., Sun, G., Xie, Y., Wang, S., Hu, X., Tang, L., Wang, J.-S. (2006). Role of Oxidative DNA Damage in Human Esophageal Carcinogenesis, Toxicologist 90:957.

 

Billam, M., Cai, Q., Mukhi, S., Tang, L., Kendall, R. J., Wang, J.-S. (2006). Molecular Targets and Toxic Effects of Microcystin-LR in F344 Rats, Toxicologist 90:176

 

Billam, M., Cai, Q., Tang, L., Wang, P., Mukhi, S., Wang, Z., Luo, H., Guan, H. and Wang, J.-S. (2005). Temporal Patterns of Microcystin-LR Contamination in Lakes of West Texas. Toxiclogist, 84:1595.

 

Cai, Q., Guan, H., Tang, L., Luo, H., Billam, M., Wang, Z., Tang, Y. and Wang, J.-S. (2005). Validation of Fumonisin Biomarkers in F344 rats. Toxicologist, 84:1308.

 

Wang, J.-S, Goldston, T., Luo, H., Billam, B., Wang, Z., Guan, H., Tang, L., Afriyie-Gyawu, E., Lovett, C., Griswold, J., Brattin, B., Huebner, H. J. and Phillips, T.D. (2005). Short-term safety evaluation of NovaSil in humans. Toxicologist, 84:1309.

 

Afriyie-Gyawu, E., Mackie, J., Dash, B., Wiles, M. C., Taylor, J., Huebner, H. J., Guan, H., Tang, L., Wang, J,-S. and Phillips, T. D. (2005). Chronic toxicological evaluation of NovaSil clay in the diet of Sprague-Dawley rats. Toxicologist 84:1402.

 

Dash, B., Afriyie-Gyawu, E., Huebner, H. J., Wang, J.-S., Jolly, P. E. and Phillips, T. D. (2005). Single nucleotide polymorphism at exon 4 in the microsomal epoxide hydrolase gene is associated with increased aflatoxin albumin adducts in the blood of humans in Ghana. Toxicologist 84:1283.

 

Tang, L., Cai, Q., Wang, Z., Luo, H., Wang, S., Xie, Y., Yu, J., Wang, K., Hu, X., Huang, T., Su, J., Sun, G., Wang, J.-S. (2005).  Validation of Fumonisin Biomarkers for Studying Human Cancer Risks. Proc AACR. 46:4061.

 

Wang, Z., Tang, Y., Sun, G., Xie, Y., Wang, S., Hu, X., Tang, L. and Wang, J.-S. (2005) Genetic Polymorphisms of CYP2E1 and GSTM1 and T1 on Susceptibility to Esophageal Cancer in Huaian, China. Proc. AACR, 46:4923.

 

Guan, G., Tang, L., Cai, Q. and Wang, J.-S. (2005). Stability and Uptake of Lycopene in Normal and Tumorigenic Human Prostate Cells. Proc. AACR. 46:6079

 

He, X-Y., Tang, L., Cai, Q., Wang, J.-S. and Hong, J-Y. (2005). Identification of human CYP2A13 as an efficient enzyme for the metabolic activation of aflatoxin B1. Proc AACR. 46:2086

 

Tang, L., Guan, H. and Wang, J.-S. (2005). Effect of Lycopene on the Growth of Stage-Specific Human Prostate Cells. Cancer Epidemiol. Biomarkers & Prev. In press

 

McKean, C., Tang, L., Billam, M., Luo, H., Tang, M., Thodorakis, C., Kendall, R. and Wang, J.-S. (2004). Combinative toxicity of multiple mycotoxin mixtures in animals and human cells. Toxicologist, 78:1035

 

Billam, M., Tang, L., Tang, M., Luo, H., McKean, C. and Wang, J.-S. (2004). Combinative toxic effects of aflatoxin B1 and microcystin-LR in the human cell lines and vertebrates. Toxicologist, 78:1030

 

Tang, L., Guan, H., Luo, H., Tang, M., Billam, M., Ding, X. and Wang, J.-S. (2004). Modulation of aflatoxin biomarkers by natural lycopene in rats. Proc. AACR. 45: 4027.

 

Luo, H., Tang, L., Tang, M., Billam, M., Huang, T., Yu, J., Wei, Z., Liang, Y., Wang, K., Zhang, Z., Zhang, L., Sun, S., Martin, C. and Wang, J.-S. (2004). Validation of green tea polyphenol biomarkers in high-risk population of liver cancer. AACR. 45: 5498.

 

Luo, H., Tang, L., Billam, M., Tang, M., Huang, T., Yu, J., Wei, Z., Liang, Y., Wang, K., Zhang, Z., Zhang, L., Sun, S. and Wang, J.-S. (2003). Chemoprevention trial of green tea polyphenols in high-risk population of liver cancer: Modulation of urinary excretion of green tea polyphenols and 8-hydroxydeoxyguanosine. Cancer Epidemiol. Biomarkers & Prev. 12:1349s (C180).

 

Tang, L., Tang, M., Luo, H., Huang, T., Yu, J., Wei, Z., Liang, Y., Wang, K., Zhang, Z., Zhang, L., Sun, S. and Wang, J.-S. (2003). Chemoprevention trial of green tea polyphenols in high-risk population of liver cancer: Modulation of serum and urinary aflatoxin biomarkers. Cancer Epidemiol. Biomarkers & Prev. 12:1349s (C181).

 

Tang, L., Jin, T., Zeng, X., Zhou, Y., and Wang, J.-S (2003). Natural lycopene inhibits the growth of prostate cancer by androgen-independent mechanism. Proc. AACR. 44: 883

 

Wang, J.-S., Huang, T.-R., Yu, J., Wei, Z., Liang, Y., Li, Y., Wang, K., Shi, J., Cui, Y., Luo, H., Tang, L., Liu, H-Q., Billam, M., Zhang, Z.-Q., and Zhang, L. (2003). Chemoprevention trial of green tea polyphenols in high-risk population of liver cancer. Proc. AACR. 44:4801

 

Wang, J.-S., Wang, S.-K, Su, J.-J, Huang, T.-R., Hu, X., Yu, J-H., Wei, Z., Liang, Y., Liu, Y., Luo, H., Sun, G-J. (2003). Food contamination of fumonisin B1 in high-risk areas of esophageal and liver cancer. Toxicologist, 72:914

 

Liu, Y., Tang L., Lian, M, Mckean, C., Wu, H., Liu, H.-Q., Theodorakis, C. W., Kendall, R. J., and Wang, J.-S. (2003). Comparative acute and combinative toxicity of aflatoxin B1 and fumonisin B1 in animals and human cells. Toxicologist, 72:913

 

Lian, M., Yang, X., Su, J-J., Huang, T-R., Wei, Z., Liang, Y., Luo, H., Wang, S-K, Sun, G-J., and Wang, J.-S. (2003). Validation of fumonisin biomarkers in high-risk population of liver cancer. Toxicologist, 72:1173.

 

Wang, J-S., Liu, Y., Theodorakis, C.W., Chiodo, L., and Kendall, R.J. (2002). Comparative acute and combinative toxicity of aflatoxin B1 and T-2 toxin in rats and fish. Toxicologist, Toxicol Sci.  66S:936

 

Liu, Y., Wan, S., Yu, S-Z., Lian, M., Jin, Y., Luo, H., Kuang, S-Y., Wu, Y., Song, L-R., Qian, G-S., and Wang, J.-S. (2002). Cocarcinogenicity of aflatoxin B1 and cyanobaterial toxins in hepatitis B virus-X gene transgenic mice. Proc AACR 43, in press

 

Wang, J-S, He X, and Busby WF, Jr. (2001). Tumorigenicity of airborne complex mixture. Toxicologist, 730.

 

Sun G, Chen J, Qian G-S, Jing X-P, and Wang J-S. (2001). A nutritional epidemiologic study in residents of Qidong with higher and lower incidence of liver cancer. Proc AACR 42, 4090.

 

Wang, J.-S., Huang, T., Su, J. J., Liang, F., Zhang, L., Zhang, Z., Wei, Z., Liang, Y., Kuang, S.-Y., Qian, G.-S., Sun, G., He, X., Kensler, T. W., and Groopman, J. D. (2000). Etiological risk factors for human hepatocellular carcinoma in Fusui, Guangxi, People’s Republic of China: an update. Proc. AACR 41: 3127

 

Li, Y., Su, J.-J., Qin, L.-L., Egner, P. A., Wang, J.-S., Groopman, J. D., Kensler, T. W., and Roebuck, B. D. (1999) Modulation of Aflatoxin B1 adducts by oltipraz in the tree shrew. Proc. AACR 40:1732.

 

Rashid, A, Wang, J.-S, Qian, G.-S, Hamilton S. R. and Groopman, J. D. (1998). Genetic alterations in hepatocellular carcinomas from People’s Republic of China. Proc. AACR 39:3719

 

Spannhake, E. W., Wang, J.-S., Shen, X., Hecht, S. S., and Groopman, J. D. (1998). Human bronchial epithelial cells metabolism of tobacco-specific nitrosamine 4-(methylnitrosa-mino)1-(3-pyridyl)-1-butanone. To ALA/ATS international Conference April 24-29, 1998, Chicago, IL.

           

Wang, J.-S., He, X., Hecht, S. S, Groopman, J. D. and Spannhake, E. W. (1997). Metabolism and activation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in primary human           bronchial epithelial cells and BEAS-2B cells. Proc. AACR  38:2263.

 

Kensler, T. W., Wang, J.-S., Kuang S.-Y., Qian, G-S., Zhu, Y-R., and Groopman, J. D. (1996).Molecular epidemiology of aflatoxin hepatocarcinogenesis in Qidong, People’s Republic of China. Modulation of Chemical Toxicity and Risk Assessment, June 9-12,1996, Tucson, Arizona.

           

Kamataki, T., Li, Y., Sasaki, M., Wang, J.-S., Groopman, J. D., and Katsuki, M. (1996). Toxicological evaluation of transgenic mice carrying the CYP3A7, encoding a human fetus-specific P450. 11th international Symposium on microsome and drug oxidation, Los Angeles.

           

Wang, J.-S., Strickland, P. T., Abubaker, S., He, X. and Groopman, J. D. (1996).  Novel aflatoxin-lysine specific monoclonal antibodies for biomarker studies. Toxicologist, 16,1133.

           

Wang, J.-S., Qian, G.-S., Yu, S.-Z., He, X., Zarba, A., Zhu, Y.-R., Wild, C. P. and Groopman, J. D. (1996). Validation of methods and long-term stability of aflatoxin-albumin adducts in samples from high risk populations for liver cancer Proc. AACR  37:711

           

Mace, K., Aguillar, F., Vautravers, P., Gonzalez, F., Wang, J.-S., Groopman, J. D., Harris, C. C. and pfeifer, A. M. A. (1996). AFB1 metabolism and p53 mutations in metabolically competent human liver epithelial cell lines. Proc. AACR  37:686.

           

Wang, J.-S., Qian, G-S., Zhu, Y-R., Zarba, A., Munoz, A., Kensler, T. W. and Groopman, J. D. (1995) Temporal patterns and persistence of aflatoxin-albumin adducts in residents of Daxin Township, Qidong, PRC, Proc. AACR  36:1682