Publications
Peer Reviewed Journal Articles:
Tang, L., Tang, M., Xu, L., Luo, H., Huang, T., Yu, J., Zhang, L., Cox, SB., Gao, W.-M and Wang, J.-S. (2008). Modulation of Aflatoxin Biomarkers in Human Blood and Urine by Green Tea Polyphenols Intervention. Carcinogenesis 29(2):411-417.
Wang, J.-S., Luo, H., Wang, P. Tang, L., Yu, J., Huang, T., Cox,
S. B., Gao, W. (2008). Validation Validation of Green Tea Polyphenol Biomarkers in a Phase II
Human Intervention Trial. Food Chem Toxicol. 46:232-240
Billam, M., Mukhi, S., Tang, L., Gao, W., and Wang, J.-S. (2008) Toxic response indicators of microcystin-LR in F344 rats following a single dose treatment. Toxcon 51(6):1068-1080.
Phillips, T. D.,
Afriyie-Gyawu, E., Williams, J., Huebner, H., N-A. Ankrah,
N-A., Ofori-Adjei, D., Jolly, P., Johnson, N.,
Afriyie-Gyawu, E., Ankrah, N.-A., Huebner, H. J., Ofosuhene, M., Kumi, J., Johnson, N. M., Tang, L., Xu, L., Jolly, P.E., Ellis, W. O., Ofori-Adjei, D., Williams, J. H., Wang, J.-S. & Phillips, T. D. (2008). NovaSil clay intervention in Ghanaians at high risk for aflatoxicosis. I. Study design and clinical outcomes. Food Additives & Contam., 25(1):76-87.
Wang, P., Afriyie-Gyawu, E., Tang, Y., Johnson, N. M., Xu, L., Tang, L., Huebner, H. J., Ankrah, N.-A., Ofori-Adjei, D., Ellis, W., Jolly, P. E., Williams, J. H., Wang, J.-S., Phillips, T. D. (2008). NovaSil clay intervention in Ghanaians at high risk for aflatoxicosis: II. Reduction in biomarkers of aflatoxin exposure in blood and urine, Food Additives & Contam., In press.
Shen, C.-L., P. Wang., Guerrier, J., Yeh, J. K. and J.-S. Wang (2008) Protective effect of green tea polyphenols on bone loss in middle-aged female rats. Osteopros Int., In press.
Afriyie-Gyawu, E., Wang, Z., Ankrah, N-A., Johnson, N. M., Tang, L., Xu, L., Ofosuhene, M., Kumi, J., Huebner, H. J., Jolly, P. E., Ellis, Taylor, R., Brattin, B., W. O., Ofori-Adjei, D., Williams, J. H., Wang, J-S., and Phillips, T. D. (2008) Clinical intervention trial with NovaSil clay in Ghanaians at high risk for aflatoxicosis: Nutrient utilization and non-nutritional factors. Food Additives & Contam., In press
Cai, Q., Tang, L. and Wang, J.-S. (2007). Validation of fumonisin biomarkers in F344 rats. Toxicol Appl. Pharmacol. 225:28-39.
Tang, L., Guan H., Ding, X. and Wang, J.-S. (2007). Modulation of aflatoxin toxicity and biomarkers by lycopene in F-344 rats. Toxicol Appl. Pharmacol. 219:10-17.
Sun,
G., Wang, S., Hu, X., Su, J., Huang, T., Yu, J., Tang, L., Gao,
W. and Wang, J.-S. (2007). Fumonisin B1 contamination of
home-grown corn in high-risk areas of esophageal and liver cancers in
Dash, B., Afriyie-Gyawu, E, Huebner, H.
J., Porter, W., Wang, J.-S, Jolly,
P. E., Phillips, T. D. (2007).
Determinants
of the variability of aflatoxin-albumin adduct levels in Ghanaians. J Toxicol. Environ. Health Part A 70:58-66.
Luo, H., Cox, SB., Gao, W.-M., Yu, J., Tang, L. and Wang, J.-S. (2006). Metabolic Profiling in Validation of Plasma Biomarkers for Green Tea Polyphenols. Metabolomics, 2(4):235-241.
Wang,
Z., Tang, L., Sun, G., Tang, Y., Xie, Y., Wang, S.,
Hu, X., Gao, W., Cox, S. B. and Wang J.-S. (2006). Etiological study of esophageal squamous cell
carcinoma in an endemic region: a population-based case control study in
Pan XP, Zhang BH, Tian K, Jones LE, Liu J,
Luo, H., Tang, L., Billam, M., Tang, M., Huang, T., Yu, J., Wei, Z., Liang, Y., Wang, K., Zhang, Z., Zhang, L., and Wang, J.-S. (2006). Phase IIa chemoprevention trial of green tea polyphenols in high-risk population of liver cancer: II. Modulation of urinary excretion of green tea polyphenols and 8-hydroxydeoxyguanosine. Carcinogenesis 27:262-268.
Billam,
M., Tang, L., Cai, Q., Mukhi, S., Guan, H., Wang, P.,
Wang, Z. and Wang, J.-S. (2006). Seasonal Variations in the
Concentration of Microcystin-LR Contamination in Lakes of
McKean, C., Tang, L., Billam, M., Tang, M., Theodorakis, C. W., Kendall, R. J. and Wang, J.-S (2006). Comparative acute and combinative toxicity of aflatoxin B1 and T-2 toxin in animals and immortilized human cell lines. J. Appl Toxicol. 26(2):139-147.
McKean, C., Tang, L., Tang, M., Billam, M., Wang, Z.,Theodorakis, C. W., Kendall, R. J. and Wang, J.-S (2006). Comparative acute and combinative toxicity of aflatoxin B1 and fumonisin B1 in animals and human cell lines. Food Chem. Toxicol. 44(6):868-876.
Liu, F., Wang,
J.-S., and Theodorakis, C.W. (2006). Genotoxicity and oxidative stress caused by sodium
arsenate and sodium perchlorate in zebrafish Danio rerio. Environ
Sci. Technol. 40:3429-3436.
Dash, B., Afriyie-Gyawu, E, Huebner, H. J., Porter, W., Wang, J.-S, Jolly, P. E., Phillips, T. D. (2006). Noninvasive identification of inter-individual variation in xenobiotic metabolizing enzymes: implications for cancer epidemiology and biomarker studies. J Toxicol. Environ. Health A.69(13):1203-1216.
He, X-Y., Tang, L., Wang, S-L., Cai, Q., Wang, J.-S. and Hong, J-Y. (2006). Efficient activation of aflatoxin B1 by cytochrome P450 2A13, an enzyme predominantly expressed in human respiratory tract. International J. Cancer, 118(11):2665-2671.
Jolly, P., Jiang, Y., Ellis, W., Awuah, R., Nnedu, O., Phillips, T., Wang, J.-S., Tang, L., Afriyie-Gyawu, E., Person, S., Williams, T. and Jolly, C. (2006). Determinants of aflatoxin levels in Ghanaians: sociodemographic factors, knowledge of aflatoxin and food handling and consumption practices. International J. Hyg. & Environ. Health 209:345-358.
Tang, L., Jin, T., Zheng, X. and Wang, J.-S. (2005). Lycopene inhibits the growth of human androgen-independent prostate cancer cells in vitro and in BALB/c nude mice. J. Nutr. 135(2): 287-290.
Afriyie-Gyawu, E., Mackie, J., Dash, B., Wiles, M.,
Wang, J.-S., Luo, H., Billam, M., Wang, Z., Guan, H., Tang, L., Goldston, T., Afriyie-Gyawu, E., Lovett, C., Griswold, J., Brattin, B., Huebner, H. J. and Phillips, T. D. (2005). Short-term safety evaluation of NovaSil in humans. Food Add. & Contam. 22 (3): 270-279.
Jiang, Y., Jolly, P. E., Ellis, W. O., Wang, J.-S., Phillips, T., Williams, J. H. (2005). Aflatoxin B1 albumin adduct levels and cellular immune status in Ghanaians. International Immunol. 17(6):807-814.
Xie, Y., Sun, G., Xiong,
C., Wang, S., Wang, H. and Wang, J.-S. (2005). Determination of T-2 toxin in staple food from KBD families
in
Wang, J.-S and Tang, L. (2004). Aflatoxin exposure and human liver cancer. J. of Toxicol, 23:249-271.
Tang, L., Tang, M., He, X., Busby, W. F., and Wang, J.-S. (2004). Tumorigenicity of airborne complex mixtures. J. Toxicol. Pharmacol. 18:134-140.
Sun, G., Xiong, C., Zhang, Y., Wang, S., Xie, Y. Wang, H., Shi, N. and Wang, J.-S. (2004). Comparison of contents of trace elements in wheat samples from the control and endemic Kashin-Beck disease areas. Trace Element & Health, 21:23-26.
Huang, T., Yu, J., Tang, L., Luo, H., Billam, M., Wei, Z.,
Liang, Y., Li, Y., Wang, K., Shi, J., Cui, Y., Zhang, Z-Q., Zhang, L., Sun, S.,
Martin, C. and Wang, J.-S. (2004). Phase IIa chemoprevention trial of green tea
polyphenols in high-risk population of liver cancer:
Wu, Y., Lu, P., Wang, J.-S., Wang, J., Wan, S., Kensler T. W., Groopman, J. D. and Qian, G.-S (2003). Correlation between the genetic polymorphism of EPHX and susceptibility to hepatocellular carcinoma, Tumor, 23:287-289.
Sun, G.-J., Qian, G.-S., Jin, X.-P., Chen, J.-G., He, X.,
Wang S.-K., Jiang, Z-K., and Wang, J.-S.
(2002). Assessment of aflatoxin exposure in residents with
high incidence of liver cancer. J.
Wang, J.-S., Abubaker, S., He, X., Sun, G., Strickland, PT., and Groopman, JD. (2001). Development of aflatoxin B1-lysine adduct monoclonal antibody for human exposure studies. Appl. Environ. Microbiol. 67:2712-2717.
Wang,
J.-S., Huang, T., Su, JJ., Liang, F., Wei, Z., Liang,
Y., Luo, H., Kuang, S-Y., Qian, G-S., Sun, G., He, X., Kensler, TW., and
Groopman, JD. (2001). Hepatocellular carcinoma and aflatoxin
exposure in
Sun G, Qian, G-S, He X, Jing X-P, Wang J-S (2001). Measurement of serum aflatoxin-albumin adducts in high-risk populations of primary liver cancer. Health Res, 30:207-210.
Li, Y., Su, J., Qin, L., Egner, PA., Wang, J-S., Groopman, JD., Kensler, TW., and Roebuck, BD. (2000). reduction of aflatoxin B1 adduct biomarkers by oltipraz in the tree shrew (Tupaia belangeri chinensis). Cancer Lett. 154:79-83.
Sun, G., He, X., Qian, G.-S., Jing, X.-P., Wang, J.-S. (2000). The detection of aflatoxin metabolites in human urine using high-pressure liquid chromatography. J. Health Toxicol. 14:250-252.
Wang,
S.S., O’Neill, J. P. Qian, G.-S., Zhu Y-R., Wang, J-B., Armenian, H., Zarba,
A., Wang, J.-S., Kensler, T.W.,
Cariello,
N. F., Groopman, J. D., and Swenberg, J. A. (1999).
Elevated HPRT mutation frequencies in aflatoxin-exposed
residents of Daxin, Qidong county, People’s Republic of
Wang, J.-S, He, X., Mulder, P. P. J., Boere, B. B., Cornelisse, J., Lugtenburg, J. and Busby, W. F. Jr. (1999). Comparative tumorigenicity of the cyclopenta-fused polynuclear aromatic hydrocarbons, aceanthrylene, dihydroaceanthrylene, and acephenanthrylene in preweanling CD-1 and BLU:Ha mouse bioassays. Carcinogenesis 20:1137-1141.
Rashid, A., Wang, J.-S., Qian, G.-S., Lu, B.-X., Hamilton, S. R. and Groopman, J. D. (1999) Genetic alterations in hepatocellular carcinomas: association between loss of chromosome 4q and p53 gene mutations. Brit. J. Cancer 80:59-66.
Wang, J.-S, Shen, X., He, X., Zhou, Y.-R., Zhang, B.-C., Wang, J.-B., Qian, G.-S., Kuang, S.-Y., Zarba, A., Egner, P. A., Jacobson, L. P., Munoz, A., Helzlsouer, K. J., Groopman, J. D. and Kensler, T. W. (1999) Protective alterations in phase 1 & 2 metabolism of aflatoxin B1 by Oltipraz in residents of Qidong, People’s Republic of China. J. Natl Cancer Inst. 91:347-354.
Wang, J.-S and Groopman, J. D. (1999) DNA damage by mycotoxins, Mutation Res. 424:167-181.
Kensler, T. W., He, X., Otieno, M., Egner, P. A., Jacobson,
L. P., Chen, B., Wang, J.-S., Zhu, Y.-R., Zhang, B.-C., Wang, J.-B., Wu. Y., Zhang Q.-N., Qian, G.-S., Kuang, S.-Y., Fang, X., Li,
Y-F., Yu, L-Y., Prochaska, H. J., Davidson, N. E., Gordon, G. B., Gorman, M.
B., Zarba, A., Enger, C., Munoz, A., Helzlsouer, K. J., and Groopman, J.D.
(1998). Oltipraz chemoprevention trial in Qidong, People’s Republic of
Zhang,
B.-C., Zhu, Y.-R., Wang, J.-B., Wu, Y., Zhang, Q.-N., Qian, G.-S., Kuang,
S.-Y., Li, Y.-F., Fang, X., Yu, L.-Y., De Flora, S., Jacobson, L. P., Zarba,
A., Egner, P. A., He, X., Wang, J.-S., Chen, B., Enger, C. L., Davidson, N. E.,
Gordon, G. B., Gorman, M. B., Prochaska, H. J., Groopman, J. D., Munoz, A.,
Helzlsouer, K. J. And Kensler, T. W. (1997). Oltipraz
Chemoprevention Trial in Qidong,
Wang, J.-S., Couburn, J., Tauber, A. I. and Zaner, K. S. (1997).role of gelsolin in actin depolymerization in adherent human neutrophils, Molecul Biol Cell. 8:121-128.
Li, Y., Yokoi, T., Katsuki, M., Wang, J.-S., Groopman, J. D., and Kamataki, T. (1997). In vivo activation of aflatoxin B1 in C57BL/6N mice carrying a human fetus-specific CYP3A7 gene, Cancer Res. 57:641-645.
Mace, K., Aguilar, F., Wang, J-S., Vautravers, P., Gomez-Lechon, M., Gonzalez, F. J., Groopman, J., Harris, C. C. and Pfeifer, A. M. A. (1997). Aflatoxin B1-induced DNA adduct formation and p53 mutations in CYP450-expressing human liver cell lines. Carcinogenesis 18:1291-1297.
Wang, J.-S., Busby, W. F. Jr., and Wogan, G. N. (1996). Comparative percutaneous absorption and tissue distribution of [3H]diacetoxyscirpenol (anguidine) in rats and mice,
Toxicol. Appl. Pharmacol. 140:264-273.
Wang, J.-S and Busby, W. F. Jr. (1996). Bacterial and human cell mutagenicity and mouse lung tumorigenicity of the oxygenated PAH, phenalenone, Fund. Appl. Toxicol. 33:212-219.
Wang,
J.-S., Qian, G.-S., Zarba, A., He, X., Zhu, Y.-R., Zhang, B.-C., Jacobson, L.,
Gange, S. J., Munoz, A., Kensler, T. W., and Groopman, J. D. (1996).
Temporal patterns of aflatoxin-albumin adducts
in hepatitis B surface antigen positive and negative residents of Daxin,
Gange, S. J., Munoz, A., Wang, J.-S., and Groopman, J. D. (1996). Variability of molecular biomarker measurements from nonlinear calibration curves.Cancer Epidemiol. Biomarker & Prev. 5(1),57-61.
Soini, Y., Chia, C. S., Bennett, W. P., Groopman, J. D., Wang, J.-S., DeBenedetti, V. M. G., Cawley, H., Welsh, J. A., Hansen, C., Bergasa, N. V., Jones, E. A., DiBisceglie, A. M., Trivers, G. E., Sandoval, C. A., Calderon, I. E., Munoz-Espinosa, L. E. and Harris, C. C. (1996). An aflatoxin-associated, mutational hotspot in the p53 tumor suppressor gene occurs in hepatocellular carcinomas from Mexico Carcinogenesis 17 (5):1007-1012.
Wang, J.-S., Busby, W. F. Jr. and Wogan, G. N. (1995). Formation and persistence of DNA adducts in organs of CD-1 mice treated with a tumorigenic dose of fluoranthene. Carcinogenesis, 16(11):2609-2616
Wang, J.-S., Busby, W. F. Jr. and Wogan, G. N. (1995). Tissue distribution of DNA adducts in preweanling BLU:Ha mice treated with a tumorigenic dose of fluoranthene. Cancer Lett. 92:9-19.
Sastry, R., Wang, J.-S., Brown, D. C., Ezekowitz, R. A. B., Tauber, A. I., and Sastry, K. N. (1995). Characterization of murine mannose-binding protein genes Mbl1 and Mbl2 reveals features common to other collectin-genes, Mammal. Genome 6:103-110.
Wang, J.-S. and Busby, W. F. Jr. (1993). Induction of lung and liver tumors by fluoranthene in a preweanling CD-1 mouse bioassay, Carcinogenesis 14:1871-1874.
Wang, J.-S., Pavlotsky, N., Tauber, A. I. and Zaner, K. S. (1993). Assembly dynamics of actin in adherent human neutrophils, Cell Motil. Cytoskeleton 26:340-348.
Ginis,
Wang, J.-S., Busby, W. F. Jr. and Wogan, G. N. (1990). Comparative tissue distribution and excretion of orally administered [3H]-diacetoxyscirpenol (anguidine) in rats and mice, Toxicol. Appl. Pharmacol. 103:430-440.
Busby, W. F. Jr., Wang, J.-S., Stevens, E. K., Padykula, R. E., Aleksejczyk, R. A. and Berchtold, G. A. (1990). Lung tumorigenicity of benzene oxide, benzene dihydrodiols and benzene diolepoxides in the BLU:Ha newborn mouse assay, Carcinogenesis 9:1473-1478.
Xu, D., and Wang, J.-S. (1988). Advances in research on trichothecenes T-2, DON and NIV. Adv. Physiol. Sci.19:103-109.
Wang, J.-S. and Sun, Q. (1988). Mutagenicity studies in vivo of zearalenone, a Fusarium mycotoxin, in mice, Acta Mycologica Sinica 7 (1):59-64.
Wang, J.-S., Zhang, Z. Y. and Zhu, X. Y. (1987). Toxicological studies (acute and accumulative toxicity, mutagenicity and cytogenetic evaluation) of Extract from Fucorose, Chinese J. Rail. Med. 15(1):52-56.
Tan, W. B., Wang, J.-S., Shan, X. N., Zhang, Z. Y. and Zhu, X. Y. (1986). Evaluation of nutritional status of preschool children from railway workers, Chinese J. Rail. Med. 14 (4):233-236
Wang, J.-S. and Xu,
Wang, J.-S. and Zhu X. Y. (1985). Investigation of aflatoxin M1 contamination in milk and milk powder, Chinese J. Rail. Med. 13 (6):354-357.
Wang, J.-S. and Jiang, Z. K. (1984). Assessment of inorganic and organic arsenic accumulation in various seafood, Chinese J. Rail. Med. 12 (5):289-292.
Tang, W. L., Jiang, Z. K., Huang, W. Q., Zhang, Z. Y., Zhu, X. Y., and Wang, J.-S. (1983). Toxicological studies of NE-109, a growth regulator of plant, in rats and mice, Chinese J. Prevent. Med. 25 (6):2020-2025.
Wang, J.-S. and Xu,
Wang, J.-S. and Xu,