Associate Professor, Molecular Epidemiology

 

 

Ph.D. Environmental and Occupational Health, University of Pittsburgh 2003

M.S. Biostatistics, University of Pittsburgh 2003

M.P.H. Occupational Medicine & Toxicology, Chinese Academy of Preventive Medicine 1997

M.D. Preventive Medicine, Nanjing Medical University 1994

 

Research Interests:

Molecular Epidemiology

Human Health Sciences

 

Classes:

ENTX 4326/6326 Principles of Toxicology II

ENTX 6100 Advance Topics in Molecular Carcinogenesis (with Drs. Kamaleshwar Singh and Greg Mayer)

 

Web Links:

Personal Webpage

 

Bio:

Dr. Weimin Gao is currently an Associate Professor in the Department of Environmental Toxicology and the Institute of Environmental and Human Health, Texas Tech University System. He received his M.D. in Preventive Medicine from the Nanjing Medical University in China. His M.P.H. in Occupational Medicine & Toxicology is from the Chinese Academy of Preventive Medicine in Beijing, China. He earned an M.S. in Biostatistics from the Graduate School of Public Health of the University of Pittsburgh. His Ph.D. in Environmental and Occupational Health is from the Graduate School of Public Health of the University of Pittsburgh as well. He was a Research Fellow in the Department of Internal Medicine at the University of Michigan’s School of Medicine. He was a Research Assistant, Research Associate and Assistant Professor at the Department of Toxicology, National Laboratory of Industrial Hygiene, Ministry of Health in Beijing. He was a Research Assistant Professor in the Department of Critical Care Medicine, School of Medicine, at the University of Pittsburgh. His current research focuses on molecular epidemiology, early detection of cancers, cancer chemoprevention, cancer therapy, and proteomics. He has published over 60 peer-reviewed articles and book chapters. He is a member of Society of Toxicology (SOT) and American Association for Cancer Research (AACR). He served as President for Society of Toxicology Lone Star Regional Chapter (LSSOT) in 2013-2014.

 

Selected Publications:

Yu Z, Gao W, Jiang E, Lu F, Zhang L, Shi Z, Wang X, Cheng L, Lv T. Interaction between IGF-IR and ER induced by E2 and IGF-I. PLoS One. 2013;8(5):e62642.

 

de Pace RC, Liu X, Sun M, Nie S, Zhang J, Cai Q, Gao W,  Pan X, Fan Z, Wang S. Anticancer activities of (-)-epigallocatechin-3-gallate encapsulated nanoliposomes in MCF7 breast cancer cells. Journal of Liposome Research. 2013;23(3):187-196.

 

Shen CL, Zhu W, Gao W, Wang S, Chen L, Chyu MC. Energy-restricted diet benefits body composition but degrades bone integrity in middle-aged obese female rats. Nutrition Research. 2013;33(8):668-676.

 

Singh KP, Treas J, Tyagi T, Gao W. DNA demethylation by 5-aza-2-deoxycytidine treatment abrogates 17 beta-estradiol-induced cell growth and restores expression of DNA repair genes in human breast cancer cells. Cancer Letters. 2012; 316(1):62-69.

 

Lu C, Zhu W, Shen CL, Gao W. Green tea polyphenols reduce body weight in rats by modulating obesity-related genes. PLoS One. 2012;7(6):e38332.

 

Lu C, Shao C, Cobos E, Singh KP, Gao W. Chemotherapeutic sensitization of leptomycin B resistant lung cancer cells by pretreatment with doxorubicin. PLoS One. 2012;7(3):e32895.

 

Shao C, Lu C, Chen L, Koty PP, Cobos E, Gao W. p53-dependent anticancer effects of leptomycin B on lung adenocarcinoma. Cancer Chemotherapy and Pharmacology. 2011; 67(6): 1369-1380.

 

Shao C, Chen L, Lu C, Shen CL, Gao W. A gel-based proteomic analysis of the effects of green tea polyphenols on ovariectomized rats. Nutrition, 2011; 27(6):681-686.

 

Chen L, Shao C, Cobos E, Wang J-S, Gao W. 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone induces CRM1-dependent p53 nuclear accumulation in human bronchial epithelial cells. Toxicological Sciences. 2010; 116(1):206-215.

 

Chen L, Moore JE, Samathanam C, Shao C, Cobos E, Miller MS, Gao W. CRM1-dependent p53 nuclear accumulation in lung lesions of a bitransgenic mouse lung tumor model. Oncology Reports. 2011; 26(1): 223-228.

 

Tian G, Guo L, Gao W. Use of compound Chinese medicine in the treatment of lung cancer. Current Drug Discovery Technologies. 2010; 7(1): 32-36.

 

Chen L, Tian G, Shao C, Cobos E, Gao W. Curcumin modulates eukaryotic initiation factors in human lung adenocarcinoma epithelial cells. Mol Biol Rep. 2010; 37(7):3105-3110.

 

Shao C, Chen S, Chen L, Cobos E, Wang J-S, Haab BB, Gao W. Antibody microarray analysis of serum glycans in esophageal squamous cell carcinoma cases and controls. Proteomics-Clinical Applications. 2009;3:923-931.

 

Gao W, Mady HH, Melhem MF, Keohavong P. Analysis of p53 mutations in histologically normal lung tissues and lung tumors from non-small cell lung cancer patients. Molecular Carcinogenesis. 2009;48(7):633-641.

 

Wang JS, Luo H, Wang P, Tang L, Yu J, Huang T, Cox S, Gao W. Validation of green tea polyphenol biomarkers in a phase II human intervention trial. Food Chem Toxicol. 2008;46(1):232-240.

 

Gao WM, Chadha MS, Berger RP, Omenn GS, Allen DL, Pisano M, Adelson PD, Clark RS, Jenkins LW, Kochanek PM. A gel-based proteomic comparison of human cerebrospinal fluid between inflicted and non-inflicted pediatric traumatic brain injury. J Neurotrauma. 2007;24(1):43-53.

 

Gao WM, Romkes M, Siegfried JM, Luketich JD, Keohavong P. Polymorphisms in DNA repair genes XPD and XRCC1 and p53 mutations in lung carcinomas of never-smokers. Mol Carcinog. 2006;45(11):828-832.

 

Gao WM, Chadha MS, Kline AE, Clark RS, Kochanek PM, Dixon CE, Jenkins LW. Immunohistochemical analysis of histone H3 acetylation and methylation--evidence for altered epigenetic signaling following traumatic brain injury in immature rats. Brain Res. 2006;1070(1):31-34.

 

Gao WM, Kuick R, Orchekowski RP, Misek DE, Qiu J, Greenberg AK, Rom WN, Brenner DE, Omenn GS, Haab BB, Hanash SM. Distinctive serum protein profiles involving abundant proteins in lung cancer patients based upon antibody microarray analysis. BMC Cancer. 2005;5:110.

 

Gao WM, Romkes M, Day RD, Siegfried JM, Luketich JD, Mady HH, Melhem MF, Keohavong P. Association of the DNA repair gene XPD Asp312Asn polymorphism with p53 gene mutations in tobacco-related non-small cell lung cancer. Carcinogenesis. 2003;24(10):1671-1676.

 

TIEHH is a major location for environmental and health sciences research at Texas Tech. The Department of Environmental Toxicology is the academic home for the core faculty at TIEHH as well as graduate students conducting research on the integration of environmental impact assessment of toxic chemicals with human health consequences.

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