Dr. Kamaleshwar Singh

Associate Professor, Environmental Genomics and Molecular Carcinogenesis

 

1997-2002, Postdoctoral Training (Environmental Cancer Genomics & Molecular Carcinogenesis), Department of Environmental Health Sciences, University of Alabama at Birmingham, Birmingham, AL

1997, Doctor of Philosophy (Molecular Genetics), University of Delhi, India

1989, Master of Science (Genetics), L N Mithila University, Darbhanga, India

1985, Bachelor of Science (Biology), L N Mithila University, Darbhanga, India

 

Research Interests:

Gene-environment interactions in human cancer development

Environmental Carcinogenesis

Toxicogenomics

Molecular Toxicology

Human Cancer Genomics

 

Classes:

ENTX 6300-002 Molecular Methods in Toxicology

ENTX 6100 Advance Topics in Molecular Carcinogenesis

 

 

Bio:

The focus of Dr. Singh’s research and teaching is on the molecular mechanistic basis for environmental carcinogen-induced genetic (DNA damage) and epigenetic changes, and susceptibility to human cancer development. Dr. Singh received his PhD degree in Molecular Genetics from University of Delhi, India. He completed postdoctoral training at the University of Alabama at Birmingham as a National Cancer Institute (NCI) postdoctoral training fellow.  In 2009, he joined the Department of Environmental Toxicology, and The Institute of Environmental and Human Health (TIEHH), Texas Tech University, Lubbock, Texas. His research interests are Molecular Toxicology, Environmental Carcinogenesis, Toxicogenomics, and Human Cancer Genomics. Dr. Singh has identified two novel genes associated with human breast and kidney cancer. His current research is focused on the genetic and epigenetic basis for environmental estrogenic-chemicals and heavy metal-induced human cancers. He has published over 30 research papers in peer reviewed journals, book chapters and has presented his research in several research meetings. He is a member of American Association of Cancer Research (AACR), American Society of Clinical Oncology (ASCO), and Society of Toxicology (SOT). Dr. Singh serves as editorial board member for peer-reviewed journals PLoS ONE, Journal of Environmental Immunology and Toxicology, and Journal of Environmental and Analytical Toxicology. He has served as scientific review panel member for federal and private funding agencies as well as reviewer for many peer-reviewed journals.

 

 

 

Selected Publications:

 

1.      J Treas, T Tyagi, KP Singh (2013) Chronic exposure to arsenic, estrogen, and their combination causes increased growth and

         transformation in human prostate epithelial cells potentially by hypermethylation-mediated silencing of MLH1. The Prostate (In Press, Epub

         ahead of Print).

 

2.      J Treas, T Tyagi, KP Singh (2012) Effects of chronic exposure to arsenic and estrogen on epigenetic regulatory genes expression and

         epigenetic code in human prostate epithelial cells. PLoS ONE 7(8):e43880.

 

3.      KP Singh, J Treas, T Tyagi, W Gao (2012) DNA demethylation by 5-aza-2-deoxycytidine treatment abrogates 17 beta-estradiol-induced cell

         growth and restores expression of DNA repair genes in human breast cancer cells. Cancer Letters 316 (1):62-9.

 

4.      C Lu, C Shao, E Cobos, KP Singh, W Gao (2012) Chemotherapeutic sensitization of leptomycin B resistant lung cancer cells by

         pretreatment with doxorubicin. PLoS ONE 7(3):e32895.

 

5.      KP Singh, R Kumari , Justin Treas, JW DuMond (2011) Chronic  exposure to arsenic causes increased cell survival, DNA damage and

         increased expression of mtTFA in human prostate epithelial cells. Chemical Research in Toxicology 24: 340-349.

 

6.      KP Singh, R Kumari, J W DuMond (2010) Simulated microgravity-induced epigenetic changes in human lymphocytes. Journal of Cellular

         Biochemistry 111:123-129.

 

7.      R Kumari, KP Singh, J W DuMond (2009) Simulated microgravity decreases DNA repair capacity and induces DNA damage in human

         lymphocytes. Journal of Cellular Biochemistry 107:723-31.

 

8.      K P Singh, R Kumari, C Pavey, D Jackson, JW DuMond (2009) Long duration exposure to cadmium leads to increased cell survival,

         decreased DNA repair capacity, and genomic instability in mouse testicular Leydig cells. Cancer Letters 279: 84-92.

 

9.      K P Singh, D Roy (2008) Allelic loss and mutations in a new ETRG-1 gene are early events in DES-induced renal carcinogenesis in Syrian

         hamster. GENE 408:18-26.

 

10.   J W DuMond, K P Singh (2007) Gene expression changes and induction of cell proliferation of mouse testicular Leydig cells by chronic

         exposure to arsenic. Journal of Toxicology and Environmental Health, Part A 70: 1150-1154.

 

11.    K P Singh, J W DuMond (2007) Genetic and epigenetic changes induced by chronic low dose exposure to arsenic in mouse testicular

         Leydig cells. International Journal of Oncology 30(1):253-260.

 

12.    J W DuMond, K P Singh, D Roy (2006) Development of a self-proliferating Leydig cell line: a hyper-sensitive E-screening model. Oncology

         Report 16(1):73-77.

 

13.    K P Singh, D Roy (2006) SKCG-1:  A new candidate growth regulatory gene at chromosome 11q23.2 in human sporadic Wilm’s tumors.

         British J Cancer 94:1524-1532.

 

14.    Q Felty, KP Singh, D Roy (2005) Estrogen-induced G1/S transition of G0 –arrested estrogen-dependent breast cancer cells is regulated by

         mitochondrial oxidant signaling. Oncogene 24, 4883-4893.

 

15.    Q Felty, WC Xiong, D Sun, S Sarkar, KP Singh, J Parkash, D Roy (2005) Estrogen-Induced mitochondrial reactive oxygen species as

         signal-transducing messengers. Biochemistry 44, 6900-6909.

 

16.    K P Singh, J A Lopez-Guerrero, A Llombart-Bosch, D Roy (2004) Age, Sex and co-exposure of N-ethyl-N-nitrosourea influence mutations in

         the ALU repeat sequences in stilbene estrogen-induced kidney tumors in Syrian hamsters. Mutagenesis 19(1):67-73.

 

17.    K P Singh, D Roy (2004) Somatic mutations in the genome of stilbene estrogen-induced Syrian hamster kidney tumors identified by DNA

         fingerprinting. Journal of Carcinogenesis 3:4

 

18.    K P Singh, D Roy (2001) Identification of breast tumor- specific novel mutation(s) in the q11.2 region of the chromosome 17 by RAPD/ AP-

         PCR fingerprinting. GENE 16: 269(1-2): 33-43.

 

19.    K P Singh, D Roy (1999) Detection of mutation through RAPD in human and experimental animal tumor samples depends upon the type of

         Taq DNA Polymerases used. International Journal of Oncology 14(4): 753-758.

 

20.    D Roy, J B Colerangle, K P Singh (1998) Is exposure to environmental or industrial endocrine disrupting estrogen-like chemicals able to

         cause genomic instability? Frontiers in Bioscience 3: d913-928.

 

 

TIEHH is a major location for environmental and health sciences research at Texas Tech. The Department of Environmental Toxicology is the academic home for the core faculty at TIEHH as well as graduate students conducting research on the integration of environmental impact assessment of toxic chemicals with human health consequences.

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