Dr. Ernest Smith
Associate Professor, Reproductive and Developmental Toxicology
Ph.D. Toxicology, Texas A&M University 1989
B.S. Agricultural Sciences, Prairie View A&M University 1983
Analytical & Biochemical Toxicology
Human Health Sciences
ENTX 6331 Reproductive & Developmental Toxicology
Ernest E. Smith is an Associate Professor in the Department of Environmental Toxicology and The Institute of Environmental and Human Health, at Texas Tech University. He received his undergraduate degree in Agricultural Sciences, with a major in animal science from Prairie View A&M University, Prairie View, Texas, and his Ph.D. in Food Science and Technology - Toxicology from Texas A&M University. His teaching and research interests include reproductive and developmental effects of environmental contaminants, as well as the development and understanding of biomarkers of the endocrine systems in developing offspring and adults. He is the author of several peer-reviewed publications and has been awarded several research grants from federal, state, and private sources to investigate various aspects of developmental biology and toxicology. Currently, his research group is focused on characterizing membrane transport proteins and the mechanisms of herbal extracts in the control of glucose transport and metabolism.
Cheng Q, Smith EE, Kirk AB, Liu F, Boylan LM, McCarty ME, Hart S, Dong L, Cobb GP, Jackson WA, Anderson TA. 2007. Fatty Acid Profile in Milk from Goats, Capra aegagrus hircus, Exposed to Perchlorate and its Relationship with Perchlorate Residues in Human Milk. Bull Environ Contam Toxicol. 79:472-477.
Cheng Q, Smith EE, Liu F, Gentles, AB., Hooper, MJ., Anderson TA. 2007. Effects of perchlorate on sodium-iodide symporter and pendrin gene expression in deer mice. Environ Toxicol. 22:390-398.
Jinqiu Zhu, René Viñas, Weimen Gao and Ernest Smith. 2007. Potential Cytotoxicity of Tecoma Stans (Bignoniaceae)to Human Liver Cancer Cells in vitro. (in press).
Fang Hu, Ernest E. Smith, James A. Carr. 2007. Effects of Larval Exposure to Estradiol on Gonadal Sex Differentiation and In Vitro Sex Steroid Secretion in African Clawed Frogs, Xenopus laevis.Gen and Comp Endocrin. (in press).
Smith , Ernest E., T.A. Anderson, C. Crabtree, J.A. Car , L.H. Du Preez, A.B. Gentles, J.P. Giesy, L. Holden, T. S. Gross, R.J. Kendall, K.R. Solomon, G. Van Der Kraak. 2007. Assessment of gonadal histology and plasma sex steroid concentrations in native bullfrogs (rana catesbeiana) collected from agricultural areas in southern Iowa (Submitted to Environ Toxicol)
Louis H. Du Preez, Nisile Kunene, Gideon J. Everson, James A. Carr, John P. Giesy, Timothy S. Gross, Alan J. Hosmer, Ronald J. Kendall, Ernest E. Smith, Keith R. Solomon, Glen J. Van Der Kraak. 2007. Reproduction, Larval Growth, and Reproductive Development in African Clawed Frogs, (Xenopus laevis) Exposed to Atrazine. Environ Sci and Tech. (accepted)
Smith, J. N., Pan, X., Gentles, A., Smith, E. E., Cox, S. B., and Cobb, G. P. 2006. Reproductive effects of hexahydro-1,3,5-trinitroso-1,3,5-triazine in deer mice (Peromyscus maniculatus) during a controlled exposure study. Environ Toxicol Chem 25, 446-51.
Hecker, M., Murphy, M. B., Coady, K. K., Villeneuve, D. L., Jones, P. D., Carr, J. A., Solomon, K. R., Smith, E. E., Van Der Kraak, G., Gross, T., Du Preez, L., Kendall, R. J., and Giesy, J. P. 2006. Terminology of gonadal anomalies in fish and amphibians resulting from chemical exposures. Rev Environ Contam Toxicol 187, 103-31
Murphy, M. B., Hecker, M., Coady, K. K., Tompsett, A. R., Higley, E. B., Jones, P. D., Du Preez, L. H., Solomon, K. R., Carr, J. A., Smith, E. E., Kendall, R. J., Van Der Kraak, G., and Giesy, J. P. 2006. Plasma steroid hormone concentrations, aromatase activities and GSI in ranid frogs collected from agricultural and non-agricultural sites in Michigan (USA). Aquat Toxicol 77, 153-66.
Murphy, M. B., Hecker, M., Coady, K. K., Tompsett, A. R., Jones, P. D., Du Preez, L. H., Everson, G. J., Solomon, K. R., Carr, J. A., Smith, E. E., Kendall, R. J., Van Der Kraak, G., and Giesy, J. P. 2006. Atrazine concentrations, gonadal gross morphology and histology in ranid frogs collected in Michigan agricultural areas. Aquat Toxicol 76, 230-45.
Park, J. W., Hecker, M., Murphy, M. B., Jones, P. D., Solomon, K. R., Van Der Kraak, G., Carr, J. A., Smith, E. E., du Preez, L., Kendall, R. J., and Giesy, J. P. 2006. Development and optimization of a Q-RT PCR method to quantify CYP19 mRNA expression in testis of male adult Xenopus laevis: comparisons with aromatase enzyme activity. Comp Biochem Physiol B Biochem Mol Biol 144, 18-28
Ramachandran, Bharath, Angella Gentles, Stephen Cox and Ernest E. Smith. 2006. Age-dependent characterization of pendrin gene expression in various tissues of deer mice. Comp Biochem Physiol B Biochem Mol Biol 145:338-45.
Smith EE, du Preez LH, Gentles BA, Solomon KR, Tandler B, Carr JA, Van Der Kraak GJ, Kendall RJ, Giesy JP & Gross TS. 2005. Assessment of laryngeal muscle and testicular cell types in Xenopus laevis (Anura Pipidae) inhabiting maize and non-maize growing areas of South Africa. African Journal of Herpetology 54(1): 69-76.
Jooste AM, Du Preez LH, Carr JA, Giesy JP, Gross TS, Kendall RJ, Smith EE, Van Der Kraak GJ, Solomon KR. 2005. Gonadal Development of Larval Male Xenopus laevis Exposed to Atrazine in Outdoor Microcosms. Environ Sci Technol. 39:5255-61.
Du Preez LH, Jansen van Rensburg PJ, Jooste AM, Carr JA, Giesy JP, Gross TS, Kendall RJ, Smith E. E, Van Der Kraak G, Solomon KR. 2005. Seasonal exposures to triazine and other pesticides in surface waters in the western Highveld corn-production region in South Africa. Environmental Pollution 135 (1): 131-141.
Coady, K. K., Murphy, M. B., Villeneuve, D. L., Hecker, M., Jones, P. D., Carr, J. A., Solomon, K. R., Smith, E. E., Van Der Kraak, G., Kendall, R. J., and Giesy, J. P. 2005. Effects of atrazine on metamorphosis, growth, laryngeal and gonadal development, aromatase activity, and sex steroid concentrations in Xenopus laevis. Ecotoxicol Environ Saf 62, 160-73.
Du Preez, L.H., Solomon, K.R., Carr, J.A., Giesy, J.P. Gross, T.S., Kendall, R.J. Smith, E.E., Van der Kraak, G. & Weldon, C. 2005. Population structure characterization of the African Clawed Fog (Xenopus laevis) in maize-growing versus non-maize-growing areas in South Africa. African Journal of Herpetology 54(1): 61-68.
Hecker, M., Park, J.-W., Murphy, M. B., Jones, P.D., Thompset, A., Solomon, K.R., Van Der Kraak, G., Carr, J.A., Smith, E.E., du Preez, L., Kendall, R.J. and Giesy, J.P. 2005. Effects of atrazine on CYP19 gene expression and aromatase activity in testes and sex steroid concentrations in plasma of male African clawed frogs (Xenopus laevis). Toxicological Sciences 86: 273–280.
Hecker M, Giesy JP, Jones PD, Jooste AM, Carr JA, Solomon KR, Smith EE, Van der Kraak G, Kendall RJ, Du Preez L. 2005. Plasma concentrations of estradiol and testosterone, gonadal aromatase activity and ultrastructure of the testis in Xenopus laevis exposed to estradiol or atrazine. Aquatic Toxicology 72:383–396.
Gentles, Angella, James Surles and Ernest E. Smith. 2005. Evaluation of Adult Quail and Egg Production Following Exposure to Perchlorate-Treated Water. Environmental Toxicol. Chem. 24:1930-1934.
Kirk AB, Martinelango PK, Tian K, Dutta A, Smith EE, Dasgupta PK. 2005. Perchlorate and iodide in dairy and breast milk. Environ Sci Technol 39:2011-7.
Solomon KR, Carr JA, du Preez LH, Giesy JP, Gross TS, Kendall RJ, Smith EE, Van Der Kraak GJ. 2005. Ecotoxicological risk assessment of atrazine in amphibians. In: Clark JM, editor. Environmental Fate and Safety Management of Agrochemical. ACS Symposium Series No 899. Washington, DC, USA: American Chemical Society. p124-137.
Kirk Andrea, Matinelango, P Kalyani, Kang Tian, Dutta, Aniruddha, Smith Ernest E., Dasgupta, Purnendu K. 2005. “Response to comment on perchlorate and iodide in dairy and breast milk." Environ. Sci and Tech. 39:5902.
Hecker M, Giesy JP, Jones PD, Jooste AM, Carr JA, Solomon KR, Smith EE, Van der Kraak G, Kendall RJ, Du Preez L. 2004. Plasma sex steroid concentrations and gonadal aromatase activities in African clawed frogs (Xenopus laevis) from South Africa. Environ. Toxicol. Chem. 23:1996-2007.
Coady K, Murphy M, Villeneuve D, Hecker M, Jones P, Carr J, Solomon K, Smith E, Van Der Kraak G, Kendall R, Giesy J. 2004. Effects of atrazine on metamorphosis, growth, and gonadal development in the green frog (Rana clamitans). J Toxicol Environ Health A. 67:941-57
Kirk, Andrea B., Ernest E. Smith, Kang Tian, Todd A. Anderson, and Purnendu K. Dasgupta. 2003. Perchlorate in Milk. Environ. Sci. Technol. 37:4979-81.
Alston, Dawn A., Bernard Tandler, Burnella Gentles, and Ernest E. Smith. 2003. Testicular histopathology in deer mice (Peromyscus miniculatus) following exposure to polychlorinated biphenyl (PCB). Chemosphere 52:283-285.
Carr, James A., Angie Gentles, Ernest E. Smith, Wanda L. Goleman, Lina J. Urquidi, Kerry Thuett, Ronald J. Kendall, John P. Giesy, Tim S. Gross, Keith Solomon, and Glen Van Der Kraak.. 2003. Response of Larval Xenopus Laevis to Atrazine: Assessment of Gonadal and Laryngeal Morphology. Environ. Toxicol. and Chem. 22:396-405.
TIEHH is a major location for environmental and health sciences research at Texas Tech. The Department of Environmental Toxicology is the academic home for the core faculty at TIEHH as well as graduate students conducting research on the integration of environmental impact assessment of toxic chemicals with human health consequences.
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