Dr. Degeng Wang

Associate Professor, Biostatistics and Molecular Toxicology

Associate Professor, Biostatistics

and Molecular Toxicology


Professional preparation:

University of Science and Technology of China Biology B.S. 1991

University of Toledo Medical Center (formerly Biochemistry and Molecular Biology Ph.D. 1998

Medical College of Ohio)


Appointments :

2015 - present Associate Professor, Department of Environmental Toxicology, The Institute of

           Environmental and Human Health (TIEHH) and The Center for Biotechnology & Genomics,

           Texas Tech University, Lubbock, TX

2014-2015 Associate Professor/Research with Dr. Zhifeng Ren, Dept. of Biology and Biochemistry,

           University of Houston, Houston, TX

2011-2014 Associate Professor, Greehey Children’s Cancer Research Institute & Department of

           Epidemiology and Biostatistics, University of Texas Health Science Center, San Antonio, TX

2007-2011 Assistant Professor, Department of Cell Biology, Microbiology and Molecule Biology

           University of South Florida, Tampa, FL

2003-2007 Scientist/Principle Investigator, San Diego Supercomputer Center (SDSC) Univ. of

           California at San Diego, La Jolla, CA


Research Interests:











2010-2013 Inclusion in the MARQUIS WHO’S WHO in America

2008 University of South Florida New Researcher Grant

1992 Fellowship, Medical College of Ohio


Professional memberships:

2013- present Editorial Board Member, Journal of Translational Medicine and Epidemiology

2011 Member, PC Committee, GENSIPS-2011

1998- present Member, International Society for Computational Biology (ISCB)

1995- present Member, American Association for the Advancement of Science (AAAS)

1994- present Member, American Association for Cancer Research (AACR)

1994-1996 Member, Ohio Academy of Sciences (AACR)



 Selected Publications:


1. Bin Yuan, Long Cheng, Kshama Gupta, Huai-Chin Chiang, Harshita B. Gupta, Gangadhara R. Sareddy, Degeng Wang, Kate Lathrop, Richard Elledge, Pei Wang, Stanton McHardy, Ratna Vadlamudi, Tyler J. Curiel, Yanfen Hu, Qinong Ye, Rong Li. (2016). Tyrosine phosphorylation regulates ERβ ubiquitination, protein turnover, and inhibition of breast cancer. Oncotarget, Vol. 7, No. 27, doi: 10.18632/oncotarget.10018.

2. Haihui Pan, Kunhua Qin, Zhanyong Guo, Yonggang Ma, Craig April, Xiaoli Gao, Alex Bokov, Jianhua Zhang, Yidong Chen, Susan Weintraub, Jian-Bing Fan, Yanfen Hu, Degeng Wang, Merry L. Lindsey, Rong Li (2014). RNA Polymerase II Pausing Factor NELF Controls Energy Homeostasis in Cardiomyocytes. Cell Report, 7(1): 79-85.

3. Zhanyong Guo, Wen Jiang, Wade Burcherds and Degeng Wang (2014). Relationship between gene duplicability and gene diversifiability in the topology of biochemical networks. BMC Genomics, 15:577.

4. Timothy Padawer, Ralph Leighty and Degeng Wang. (2012). Duplicate gene enrichment and expression pattern diversification in multi-cellularity. Nucleic Acid Research, 40(16): 7597-7605.

5. Brewster Hayles, Sailu Yellaboia and Degeng Wang. (2010). Comparing transcription rate and mRNA abundance as parameters for biochemical pathway and network analysis. PLoS One, 5(3), e9908.

6. Degeng Wang. (2008). Discrepancy between mRNA and protein abundance: Insight from information retrieval process in computers. Computational Biology and Chemistry, 32(6), 462-468.

7. Degeng Wang. (2005). “Molecular gene”: Interpretation in the right context. Biology and Philosophy, 20(2-3), 453-464.

8. Degeng Wang and Michael Gribskov. (2005). Examining the architecture of cellular computing through a comparative study with a computer. Journal of the Royal Society Interface, 2(3), 187-195.

9. Sung Hee Baek, Chrissa Kioussi, Paola Briata, Degeng Wang, H. D. Nguyen, Kenneth A. Ohgi, Christopher K. Glass, Anthony Wynshaw-Boris, David W. Rose, and Michael G. Rosenfeld. (2003). Regulated subset of G1 growth-control genes in response to derepression by the Wnt pathway. Proc. Natl. Acad. Sci. USA, 100(6), 3245-3250.

10. Degeng Wang, Jeffrey F. Harper, and Michael Gribskov. (2003). Systematic trans-genomic comparison of protein kinases between Arabidopsis and Saccharomyces cerevisiae. Plant Physiology 132(4), 2152-2165.

11. Jason Tchieu, Fariba Fana, J. Lynn Fink, Jeffrey Harper, Murlidharan Nair, Douglas W. Smith, Ken Steube, Tobey Tam, Stella Veretnik, Degeng Wang, and Michael Gribskov. (2003). The PlantsP and PlantsT functional genomics databases. Nucleic Acid Research, 31(1), 342-344.

12. Degeng Wang, Sandip Patil, Wenhui Li, Elizabeth E. Humphrey, Michael G. Brattain, and Gillian M. Howell. (2002). Activation of the TGF-alpha autocrine loop is downstream of IGF-I receptor activation during mitogenesis in growth factor dependent human colon carcinoma cells. Oncogene, 21(18), 2785-2796.

13. Gillian M. Howell, Lisa E. Humphrey, Rana Awad, Degeng Wang, Alan Koterba, Basker Periyasami et al. (1999). Aberrant expression of autocrine TGFα in a highly progressed human colon carcinoma cell line at a quiescent state. Journal of Biological chemistry, 273(15), 9214-9223.

14. Dianhua Jiang, Haisu Yang, James K.V. Willson, Jiurong Liang, Lisa E. Humphrey, Elizabeth Zborowska, Degeng Wang, Jason Foster, Robert Fan, and Michael G. Brattain. (1998). Autocrine transforming growth factor alpha provides a growth advantage to malignant cells by facilitating re-entry into the cell cycle from sub-optimal growth states. Journal of Biological Chemistry, 273(47), 31471-31479.

15. Degeng Wang, Wenhui Li, Wen Jiang, Lisa E. Humphrey, Gillian M. Howell and Michael G. Brattain. (1998). Autocrine TGFα expression in the regulation of initiation of human colon carcinoma growth. Journal of Cellular Physiology, 177(3), 387-395.


TIEHH is a major location for environmental and health sciences research at Texas Tech. The Department of Environmental Toxicology is the academic home for the core faculty at TIEHH as well as graduate students conducting research on the integration of environmental impact assessment of toxic chemicals with human health consequences.


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